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10-Minute Presentation

Medical, Urban, and Veterinary Entomology

10-min: MUVE, Urban Entomology and Pest Control 1

Isocycloseram: Novel model of action & broad spectrum of activity against urban pests and public health disease vectors

Tuesday, November 12, 2024
8:24 AM – 8:36 AM MST
Location: Phoenix Convention Center, 225 B, PCC
Oral Presentation

    Presenting Author(s)

  • Raj K. Saran

    Global Product Biology Expert
    Syngenta
    Vero Beach, Florida

    • Co-Author(s)

  • BS

    Brigitte Slaats

    Global Technical Manager
    Syngenta
    Basel, Basel-Stadt, Switzerland

  • BB

    Brittny Blakely

    Research Specialist
    Syngenta
    Vero Beach, Florida

  • MH

    Mark Hoppe

    Global Product Biology Expert
    Syngenta
    Stein, Schaffhausen, Switzerland

  • LV

    Laura Vavassori

    Global Technical Manager
    Syngenta
    Basel, Basel-Landschaft, Switzerland

Isoxazolines inhibit γ-aminobutyric acid chloride channels in insects and acarids by binding to postsynaptic receptors. This prevents chloride influx, leading to depolarization/hyperexcitation, paralysis, and death. Isocycloseram proved to be active against both laboratory and field populations of German cockroaches at lower or equal doses to those of other chemicals. Ants, bed bugs, and mosquitoes readily ingested lethal doses of isocycloseram from different surfaces treated with formulated products. Given its non-repellency, delayed toxicity, and activity at very low rates, isocycloseram can be a very effective compound against quasi-social, social, and other human disease vector pests.