Existing pest control options are becoming less effective due to resistance development, while increasing product safety requirements further limit available options. Identifying novel resistance-breaking and safe modes of action for next-generation products is key to ensuring future agricultural productivity, sustainability, and safety. A comprehensive understanding of the effects of active molecules at their target site in the organism has become increasingly important. In parallel, the use of “omics”-based approaches for mechanistic studies has greatly expanded, encompassing technologies to characterize various biological products, including genes (genomics), RNA (transcriptomics), proteins (proteomics) and metabolites (metabolomics). This presentation will focus on how “omics” technologies have contributed to the study of modes of action of biologically active molecules in the field of pesticides - and what they promise for the identification of next generation solutions.
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