Advances in RNAi for pest control: Insights and applications from Brazil

RNA interference (RNAi) technology represents a promising approach for sustainable pest management in agriculture. This presentation will focus on the advances and challenges associated with RNAi-based bioinsecticides, particularly topical applications (spray-induced gene silencing, SIGS). We will explore the establishment of topical RNAi for biotechnological purposes, highlighting its potential to offer environmentally sustainable and highly specific pest control solutions compared to traditional agrochemicals. Key technological bottlenecks, including RNAi molecule stability and efficient delivery methods under field conditions, will be discussed. Further, we will address the regulatory landscape, emphasizing biosafety and risk assessments necessary for the approval and commercialization of RNAi-based products. Insights into the potential off-target effects and strategies to mitigate these risks will be provided. Additionally, the contributions of RNAi technology to plant science and food production will be examined, showcasing how these innovations can lead to improved crop resilience and reduced reliance on chemical pesticides. By examining current developments and future prospects, this talk aims to provide a comprehensive overview of the role of RNAi bioinsecticides in advancing sustainable agriculture.