The U.S. potato industry commonly uses neonicotinoid insecticides to target insect pests, but this group of pesticides is under scrutiny by food/nursery retailers and regulators. As the continued use of neonicotinoids is in jeopardy, the potato industry needs robust and enduring alternatives that are sustainable and address consumer concerns. Neonicotinoids have been standard for the management of Colorado potato beetle (Leptinotarsa decemlineata) in many regions of the U.S. Here, we compared 5 season-long insecticide programs: (1) an untreated, (2) an at-plant neonicotinoid grower standard, (3) a non-neonicotinoid insecticide program with an at-plant cyantraniliprole treatment, (4) a non-neonicotinoid program with no at-planting insecticide application, and (5) a beneficial-friendly non-neonicotinoid program. We conducted a replicated field trial and recorded Colorado potato beetle and beneficial insect numbers throughout the growing season. We compared the efficacy of the tested programs for reducing populations below economic thresholds. Non-neonicotinoid programs provided an equivalent level of insect control to the neonicotinoid grower standard programs, and the number of insecticide applications was similar. More beneficial insects were present in the non-neonicotinoid programs. In summary, options for transitioning away from a reliance on neonicotinoids are available for effective Colorado potato beetle management.