D3365: Dual roles of a sigma glutathione S-transferase in xenobiotic adaptation of Leptinotarsa decemlineata

Tuesday, November 12, 2024

9:00 AM – 5:00 PM MST

Location: Phoenix Convention Center, Exhibit Hall 6, PCC

Presenting Author(s)

Sonu Koirala B K (she/her/hers)

Postdoctoral Scholar
The Pennsylvania State University
State College, Pennsylvania

Co-Author(s)

TM

Timothy W. Moural (he/him/his)

Principle Investigator
The Pennsylvania State University
University Park, Pennsylvania
QC

Qi-Ren Chen

The Pennsylvania State University
University Park, Pennsylvania
Andrei Alyokhin

Professor
University of Maine
Orono, Maine
FZ

Fang (Rose) Zhu, Ph.D. (she/her/hers)

Assistant Professor
The Pennsylvania State University
University Park, Pennsylvania

Glutathione S-transferases (GSTs) constitute a large family of multifunctional enzymes that are involved in Phase II metabolic detoxification of xenobiotics. GSTs catalyze the conjugation reaction of lipophilic compounds with the thiol group of reduced glutathione resulting in more water-soluble and less toxic products that can be excreted out of organisms. To date, the roles of GSTs in co-opted insecticide resistance and host plant adaptation in the Colorado potato beetle (CPB), a notorious agriculture pest on Solanaceae crops, remain insufficient explored. In the current study, we conducted a structural and functional analysis of a sigma subclass GST, LdGSTS8, exploring its potential involvement in xenobiotic adaptation.